Keywords
variance stabilization
expression noise
paired simulation
reproducibility
Abstract
We evaluated variance stabilization for gene-expression screening under 39% expression noise. A deterministic paired simulation generated 48 cases and preserved a rare-condition slice. Mean feature recovery changed from 0.520 to 0.566; the paired difference was +0.046 (95% interval +0.044 to +0.048). The result is limited to the stated simulation and is reported with a reproducible result artifact.
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