Abstract
This review examines governed curriculum learning for regenerative bioinformatics through an evidence-centered design lens. The analysis asks which network signals justify experimental follow-up. It treats the relevant unit as a complete pathway from data or physical observations to representation, model output, human interpretation, and accountable action. The cited literature is synthesized without inventing experiments or unreported performance values. Particular attention is given to pathway enrichment being treated as causal proof. The review argues that credible translation requires explicit evidence boundaries, uncertainty-aware evaluation, author-visible traceability, and a documented route for intervention. The resulting framework supports temporomandibular-joint regeneration research while distinguishing component promise from system readiness.
References
Bengio, Y., Louradour, J., Collobert, R., & Weston, J. (2009). Curriculum learning. In Proceedings of the 26th International Conference on Machine Learning (pp. 41-48).
Deng, H., Zou, D., Ma, R., Luo, H., Cao, Y., & Kang, Y. (2025). Boosting the generalization and reasoning of vision language models with curriculum reinforcement learning. arXiv preprint arXiv:2503.07065.
Han, Z., Chen, W., Han, Y., Mao, R., & Qin, J. (2026). Fast diversified top-k rule discovery via user-guided embeddings. IEEE Transactions on Knowledge and Data Engineering, 38, 1739–1753.
Lambin, P., Rios-Velazquez, E., Leijenaar, R., Carvalho, S., van Stiphout, R. G. P. M., Granton, P., Zegers, C. M. L., Gillies, R., Boellard, R., Dekker, A., & Aerts, H. J. W. L. (2012). Radiomics: Extracting more information from medical images using advanced feature analysis. European Journal of Cancer, 48(4), 441-446. https://doi.org/10.1016/j.ejca.2011.11.036
Lou, Y., Tao, R., Weng, X., Sun, S., Yang, Y., & Ying, B. (2023). Bioinformatics analysis of synovial fluid-derived mesenchymal stem cells in the temporomandibular joint stimulated with IL-1β. Cytotechnology, 75(4), 325–334.
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., ... & Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71. https://doi.org/10.1136/bmj.n71
Schulman, J., Wolski, F., Dhariwal, P., Radford, A., & Klimov, O. (2017). Proximal policy optimization algorithms. arXiv preprint arXiv:1707.06347.
Steyerberg, E. W. (2019). Clinical prediction models (2nd ed.). Springer. https://doi.org/10.1007/978-3-030-16399-0
Tao, J., Lyu, R., & Cao, X. (2026). A Deep Learning-Based Automated Content Moderation Framework for Online Platforms. Future-Adaptive Intelligence and Lifelong Systems, 1(1).
Vaswani, A., Shazeer, N., Parmar, N., Uszkoreit, J., Jones, L., Gomez, A. N., Kaiser, Ł., & Polosukhin, I. (2017). Attention is all you need. Advances in Neural Information Processing Systems, 30.
